On the first day of March 2021, World Bank just published the newest analysis report for seven secondary cities in Mekong Region (Bac Lieu, Ben Tre, Long Xuyen, Soc Trang, Tan An, Vi Thanh, Vinh Long). The study is apart of World Bank support Vietnam government in development policy operation and Mekong Master Plan ( 120.NQ-CP). The analysis presented based on the current database and identified highlight issues in cities, provinces, nationwide in urban planning strategy. Moreover, the researchers' team also provides a strong understanding & comment on how to strengthen disaster and support regional sustainable development with the great collaboration from officials & stakeholders' inputs. For the best cooperation between region & state level by the priority list guidelines could contribute effectively for Mekong Delta plans in the Vietnam development overview.